Which of the following is NOT a potential treatment for salicylate poisoning?

The administration of a reversible COX-inhibitor is not a potential treatment for salicylate poisoning because salicylates, such as aspirin, are non-selective inhibitors of cyclooxygenase (COX) enzymes. In cases of salicylate poisoning, patients typically experience metabolic acidosis, respiratory alkalosis, and various gastrointestinal symptoms. The focus of treatment is on alleviating these symptoms and enhancing the elimination of salicylates from the body.

Activated charcoal is commonly used as an immediate treatment after ingestion of salicylates, as it can absorb the drug in the gastrointestinal tract and reduce its systemic absorption. Sodium bicarbonate can help to correct metabolic acidosis and promote the renal excretion of salicylate by alkalinizing the urine. Hemodialysis may be indicated in severe cases of salicylate poisoning, especially when there is a need for rapid removal of the drug from systemic circulation.

In contrast, a reversible COX-inhibitor would not address the underlying complications of salicylate toxicity and might even complicate the patient's condition by further inhibiting cyclooxygenase pathways, which are already disrupted due to the excessive salicylate levels. Thus, it is not considered