Which herbal supplement is known for most inhibiting monoamine oxidase (MAO)?

St. John's wort is widely recognized for its ability to inhibit monoamine oxidase (MAO), an important enzyme that breaks down neurotransmitters such as serotonin, dopamine, and norepinephrine in the brain. By inhibiting MAO, St. John's wort can help increase the levels of these neurotransmitters, which may contribute to its effectiveness in managing symptoms of mild to moderate depression.

The activity of St. John's wort concerning MAO inhibition highlights its potential as an antidepressant, which is reflected in numerous studies and its traditional use in herbal medicine. This attribute makes it distinct compared to other herbal supplements that do not share the same level of MAO inhibitory activity.

For context, while garlic, Ginkgo biloba, and saw palmetto have their own health benefits, they are not primarily characterized by significant MAO inhibition. Garlic is often noted for its cardiovascular benefits, Ginkgo biloba for its potential cognitive enhancement, and saw palmetto commonly for prostate health, none of which prominently feature MAO inhibition in their profiles as does St. John's wort.