What is true regarding analgesic effects of antidepressants?

The analgesic effects of antidepressants are indeed most accurately attributed to their blockade of serotonin and norepinephrine reuptake. This mechanism enhances the availability of these neurotransmitters in the synaptic cleft, which plays a significant role in modulating pain pathways. Both serotonin and norepinephrine are important in the descending pain control pathways in the central nervous system, thus contributing to analgesic effects when reuptake is inhibited.

While some antidepressants do primarily block serotonin reuptake, their pain-relieving properties often arise from their ability to also influence norepinephrine levels, making option D the most appropriate answer. Higher doses resulting in therapeutic analgesic effects can vary by individual and by the type of pain, making the assertion about higher doses for analgesic effects not universally applicable. Additionally, the claim that antidepressants are ineffective in neuropathic pain is misleading, as certain types of antidepressants, such as those that affect norepinephrine, have been found to be effective for neuropathic pain conditions.