What effect does fentanyl have on the plasma concentration of etomidate when administered together?

When fentanyl is administered together with etomidate, it can interact in such a way that the plasma concentration of etomidate may increase. Fentanyl, as an opioid, has the potential to alter the metabolism and pharmacokinetics of other drugs. Specifically, it may inhibit certain metabolic pathways, leading to decreased clearance of etomidate from the body.

As etomidate is primarily metabolized by the liver, any factors that impact liver function or enzyme activity can influence the concentration of etomidate in the plasma. Therefore, the presence of fentanyl can lead to a higher plasma concentration of etomidate due to its metabolic interactions, potency as an analgesic, and how it can affect drug distribution in the presence of anesthesia.

Understanding the potential interactions between these medications is crucial for safe anesthesia practice and ensuring appropriate dosing to avoid adverse effects.